Aucte intermittent porphyria and epilepsy.
نویسندگان
چکیده
A 14-year-old boy had suffered from intermittent acute hepatic porphyria, myoclonic convulsions and mental retardation (Lennox-Gastaut syndrome). The porphyria was treated by stopping the administration of phenobarbitone and phenytoin. Sodium valproate at a dose of 70 mg/kg per day lessened the severity and frequency of convulsive crises.
منابع مشابه
Treatment of seizures in acute intermittent porphyria: safety and efficacy of gabapentin
Treatment of seizures in acute intermittent porphyria represents a therapeutic dilemma. Patients needing chronic therapy often experience acute porphyric attacks due to increased hepatic metabolism induced by the antiepileptic drugs themselves. Gabapentin is a new antiepileptic drug not appreciably metabolized by the liver in humans, and it appears to be safe and effective in the maintenance th...
متن کاملNeuropsychiatric porphyria in patients with refractory epilepsy: report of three cases.
OBJECTIVES Although epileptic seizures are an infrequent feature of acute attacks of the neuropsychiatric porphyrias, there are no significant reports of porphyria in chronic epilepsy. This paper attempts to redress the balance. METHODS Three case reports, including detailed laboratory and molecular diagnostics. RESULTS Two patients with variegate porphyria and one with acute intermittent p...
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متن کاملThe Impact of Gonadal Hormones on the Expression of Human Neurological Disorders
The effects of gonadal steroids on neurological well-being and disease constitute a rich and rapidly expanding area of basic and clinical neuroscience. Gonadal hormones exert potent effects on monoaminergic, cholinergic and peptidergic pathways as well as neurosteroidogenesis which, in turn, impact normal brain organization and function. A spectrum of human neurological conditions are influence...
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عنوان ژورنال:
- Archives of disease in childhood
دوره 54 8 شماره
صفحات -
تاریخ انتشار 1979